Table 1.
Subject characteristics and measurements of physiological examinations and quantitative CT (n = 188).
| mean ± SD (range) | |
|---|---|
| Age | 63.7 ± 8.37(45–79) |
| Gender, male:female | 88:100 |
| Body mass index | 27.40 ± 5.93 (12.29–44.97) |
| Smoking pack years | 51.04 ± 24.06 (10.50–150.00) |
| GOLD stage 0:I:II:III:IV | 15:7:62:61:43 |
| BODE index | 3.25 (0–7) |
| %FEV1 predicted post-bronchodilator | 48.76 ± 23.57 (11–150) |
| FEV1/FVC ratio post-bronchodilator | 0.46 ± 0.15 (0.18–0.89) |
| Raw (cmH2O/L/s) | 4.04 ± 1.94 (0.81–11.59) |
| sGaw (L//s/cmH2 O/L) | 0.07 ± 0.05 (0.01–0.44) |
| FEF25–75% (L/s) | 0.65 ± 0.75 (0.11–6.16) |
| %LAA−950ins | 17.19 ± 13.13 (0.08–55.89) |
| %LAA−856exp | 42.76 ± 21.09 (2.26–76.75) |
| RVC−856 to −950 (%) | −28.94 (−75.42 to −4.83) |
| E/I-ratio MLD(%) | 91.69 (76.45–98.34) |
| Pi10 (mm) | 3.80 ± 0.11 (3.47–4.22) |
| Mean airway wall area% (subsegmental) | 65.83 ± 2.44 (57.69–71.78) |
| Mean airway wall thickness (mm) (subsegmental) |
1.41 ± 0.15 (1.05–1.79) |
| Mean luminal diameter (mm) (subsegmental) | 3.45 ± 0.51 (2.22–5.19) |
| Visual assessment of severity of airway disease* 1:2:3:4 |
9:31:64:84 |
Abbreviations: GOLD = the global initiative for obstructive lung disease, BODE = the body-mass index, airflow obstruction, dyspnea, and exercise capacity index, FEV = forced expiratory volume, FVC = forced vital capacity, Raw = airway resistance, sGaw = specific airway conductance, FEF25–75% = the average forced expiratory flow during the mid (25–75%) portion of the FVC, %LAA−950ins = percents of low attenuation areas ≤−950 Hounsfield unit on inspiratory CT, %LAA−856exp = percents of low attenuation areas ≤−856 Hounsfield unit on expiratory CT, RVC (relative volume change) −856 to −950 = change of the relative volume of voxels between −856 to −950 HU from inspiratory to expiratory CT (%) (see the text for details), E/I-ratio MLD = ratio of expiratory mean lung density to inspiratory mean lung density (%), Pi10 = square root of the wall area at an internal airway perimeter of 10 mm.
The severity of airway disease was assessed based on the degree of bronchial wall thickening. See the text for details.