. 2016 Nov 18;16(1):10–18. doi: 10.1016/j.jcm.2016.08.008

Table 2.

Summary of Meta-analyses on Plasma Lipids and the Incidence of Cardiovascular Disease and Stroke

Meta-analysis Authors and Date	No. of Studies in Meta-analysis	No. of Participants in Meta-analysis	Average Servings or Amount per Day	Main Findings of Meta-analysis	Q Test P Value	I² Statistic	Egger or Begg Test P Value
Kelly et al 2007^¹⁰	9	738 (all with CHD)	30 g	TC ↓ 7.0 mg/dL, P < .0001	NS for all 4	NS for all 4	NS
				LDL ↓ 7.7 mg/dL, P < .0001
				HDL 0.0 mg/dL, P = .95
				Trigs ↓ 0.9 mg/dL, P = .84
Hollænder et al 2015^¹¹	24	2275 (2/3 with hypercholesterolemia)	28 g	TC ↓ 4.6 mg/dL, P < .001	.01	40%	NR
				LDL ↓ 3.5 mg/dL, P = .003	.02	38%
				HDL ↓ 0.4 mg/dL, P = .59	.17	21%
				Trigs ↓ 3.5 mg/dL, P = .10	.49	0%
Anderson et al 2000^¹²	4	179 961	NR	Cardiovascular disease RR = 0.64, P < .05	.94	NR	NR
Mellen et al 2008^¹³	7	285 376	2.5	Cardiovascular disease RR = 0.63, P < .0001	.07	NR	0.001
Ye et al. 2012^⁹	10	408 605	High vs low	Cardiovascular disease RR = 0.79, P < .01	.82	0%	.03
Tang et al 2015^¹⁴	14	400 492	High vs low	Cardiovascular disease RR = 0.79, P < .001	.54	0%	.63
Fang et al 2015^¹⁵	6	498 487	High vs low	Stroke RR = 0.86, P < .05	NR	0%	.84
Chen et al 2016^¹⁶	5	204 895	High vs low	Stroke RR = 0.92 NS	.08	53%	.96
Wei et al 2016^¹⁷	9	760 637	High vs low	Cardiovascular mortality RR = 0.81, P < .05	.01	57%	.83
Chen et al 2016^¹⁸	12	847 024	High vs low	Cardiovascular mortality RR = 0.82, P < .05	.58	0%	.37

CHD, coronary heart disease; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NR, not reported; NS, not significant; RR, relative risk; TC, total cholesterol; Trigs, triglycerides.