Table 5.
One step individual participant data meta-analysis of secondary outcomes, stratified by dosing frequency
| Outcomes | Bolus dosing | Daily or weekly dosing | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No of trials | Proportion with ≥1 event, control group (%) | Proportion with ≥1 event, intervention group (%) | Adjusted odds ratio (95% CI)* | P value | No of trials | Proportion with ≥1 event, control group (%) | Proportion with ≥1 event, intervention group (%) | Adjusted odds ratio (95% CI)* | P value | ||
| Upper respiratory tract infection | 8 | 606/1052 (57.6) | 730/1284 (56.9) | 1.03 (0.86 to 1.24) | 0.72 | 11 | 1050/2234 (47.0) | 1077/2449 (44.0) | 0.88 (0.78 to 1.00) | 0.05 | |
| Lower respiratory tract infection | 4 | 424/1889 (22.4) | 427/1922 (22.2) | 0.96 (0.82 to 1.13) | 0.60 | 5 | 118/1396 (8.5) | 134/1491 (9.0) | 0.98 (0.75 to 1.28) | 0.88 | |
| Use of antimicrobials for treatment of ARTI | 4 | 201/348 (57.8) | 203/367 (55.3) | 0.79 (0.56 to 1.10) | 0.16 | 5 | 196/635 (30.9) | 210/754 (27.9) | 0.87 (0.67 to 1.13) | 0.31 | |
| Work or school absence due to ARTI | 4 | 219/409 (53.5) | 196/411 (47.7) | 0.78 (0.59 to 1.04) | 0.10 | 3 | 102/223 (45.7) | 123/273 (45.1) | 1.03 (0.71 to 1.48) | 0.88 | |
| Serious adverse event of any cause | 10 | 107/2822 (3.8) | 115/3070 (3.7) | 1.00 (0.74 to 1.35) | 0.99 | 15 | 109/2549 (4.3) | 106/2783 (3.8) | 0.97 (0.73 to 1.30) | 0.86 | |
| Death due to any cause | 10 | 29/2822 (1.0) | 35/3070 (1.1) | 1.29 (0.71 to 2.35) | 0.40 | 15 | 19/2549 (0.7) | 21/2783 (0.8) | --† | --† | |
| Death due to ARTI or respiratory failure | 10 | 4/2797 (0.1) | 3/3038 (0.1) | 0.61 (0.12 to 3.02) | 0.54 | 15 | 3/2533 (0.1) | 3/2765 (0.1) | --† | --† | |
| Death due to any infection | 10 | 8/2801 (0.3) | 5/3040 (0.2) | 0.55 (0.17 to 1.80) | 0.32 | 15 | 7/2537 (0.3) | 11/2773 (0.4) | --† | --† | |
| Hospital admission or emergency department attendance due to ARTI | 6 | 4/2081 (0.2) | 6/2124 (0.3) | --† | --† | 5 | 43/1805 (2.4) | 34/1862 (1.8) | --† | --† | |
| Hypercalcaemia | 8 | 8/1062 (0.8) | 11/1303 (0.8) | --† | --† | 6 | 1/677 (0.1) | 1/808 (0.1) | --† | --† | |
| Renal stones | 6 | 0/764 (0.0) | 1/1011 (0.1) | --† | --† | 8 | 4/943 (0.4) | 1/1123 (0.1) | --† | --† | |
ARTI=acute respiratory tract infection.
*Adjusted for age, sex, and study duration.
†Values could not be estimated as model did not converge.