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. 2017 Feb 16;7:42. doi: 10.3389/fcimb.2017.00042

Figure 4.

Figure 4

Losartan and captopril treatments reduce activation of Plasmodium-specific CD8+ T cells. Percentage of cells expressing the markers of activation CD69, CD160, CD44, and CD62L were evaluated at day 6 post infection in WT OT-I cells (CD8+CD45.1+) recovered from the spleen of recipient mice (CD45.2+) infected with OVA-PbA and treated with vehicle, losartan (20 mg/kg/day) or captopril (20 mg/kg/day). The gating strategy used for the flow cytometry analysis is indicated in the Materials and Methods section. (A–C) Representative dot plots, percentage of CD69+ OT-I cells among total OT-I cells in the spleen (*p < 0.0001), and expression of CD69 (*p = 0.0003). (D–F) Representative dot plots, percentage of CD160+ OT-I cells among total OT-I cells in the spleen (*p < 0.0001), and expression of CD160 (*p = 0.0001). (G–I) Representative dot plots, percentage of CD44+ OT-I cells among total OT-I cells in the spleen (*p < 0.0001), and expression of CD44 was evaluated (*p = 0.0112). (J–L) Representative dot plots, percentage of CD62L+ OT-I cells among total OT-I cells in the spleen (*p = 0.0047), and expression of CD62L (p = 0.7873). *In relation to WT OT-I cells from infected mice treated with vehicle. Data are means ± SEM of five mice per group and are pooled from three independent experiments with similar results.