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. 2017 Feb 16;7:42. doi: 10.3389/fcimb.2017.00042

Figure 8.

Figure 8

Losartan and captopril treatments reduce chemokine receptor expression in Plasmodium-specific CD8+ T cells. Percentage of cells expressing CD11a, CCR5, and CXCR3 were evaluated in WT OT-I cells (CD8+CD45.1+) harvested from the spleen of recipient mice (CD45.2+) infected with OVA-PbA and treated with vehicle, losartan (20 mg/kg/day), or captopril (20 mg/kg/day). The gating strategy used for the flow cytometry analysis is indicated in the Materials and Methods section. (A–C) Representative dot plots, percentage of CD11a+ OT-I cells among total OT-I cells in the spleen (p = 0.1721), and expression of CD11a (p = 0.7627). (D–F) Representative dot plots, percentage of CCR5+ OT-I cells among total OT-I cells in the spleen (*p = 0.0005), and expression of CCR5 (*p = 0.0001). (G–I) Representative dot plots, percentage of CXCR3+ OT-I cells among total OT-I cells in the spleen (*p = 0.0053), and expression of CXCR3 (*p = 0.0001). *In relation to WT OT-I cells from infected mice treated with vehicle. Data are means ± SEM of four mice per group and are representative of three independent experiments with similar results.