Table 4.
Circulating microRNAs (miRNAs) profiled in selected hepatitis C studies.
| Platform/assay | Biological fluid | Notable miRNAs detected (arrows indicate direction of expression) | Data normalization | Reference |
|---|---|---|---|---|
| RT-qPCR TaqMan MicroRNA assays (Applied Biosystems) | Serum | miR-122↑ | No information provided | Bihrer et al. (192) |
| RT-qPCR TaqMan MicroRNA assays (Applied Biosystems) | Serum | miR-122↑, miR-34a↑, miR-16↑ | cel-miR-238 | Cermelli et al. (193) |
| RT-qPCR TaqMan MicroRNA assays (Applied Biosystems) | Serum | miR-122↑, miR-192↑ | Normalized for initial serum input | van der Meer et al. (194) |
| RT-qPCR TaqMan MicroRNA assays (Applied Biosystems) | Serum | miR-122↑ | cel-miR-39 | Wang et al. (195) |
| RT-qPCR TaqMan MicroRNA assays (Applied Biosystems) | Serum | miR-122↑, miR-155↑ | cel-miR-39 | Bala et al. (66) |
| miRNA PCR arrays | Serum | miR-122↑, miR-134↑, miR-424-3p↑, miR-629-5p↑ | U6 snRNA | Zhang et al. (196) |
| Individual RT-qPCR assays | ||||
| RT-qPCR TaqMan MicroRNA assays | Serum | miR-122↑ | cel-miR-39 | Su et al. (198) |
| TaqMan RT-qPCR OpenArray chips | Plasma | miR-122↑, miR-885-5p↑, miR-494↓ | Quantile normalization | El-Diwany et al. (200) |
| Individual TaqMan RT-qPCR assays | ath-miR-159a | |||
| miScript miRNA PCR array | Serum and plasma | miR-20a↑, miR-92a↑ | cel-miR-39 | Shrivastava et al. (202) |
| Individual TaqMan RT-qPCR assays | ||||
| miRNA microarray (Agilent) | Serum | miR-134↑, miR-320c↑, miR-483-5p↑ | Percentile shift normalization | Shwetha et al. (203) |