Table 5.
Circulating microRNAs (miRNAs) profiled in selected infectious disease studies.
| Pathology | Platform/assay | Biological fluid | Notable miRNAs detected (arrows indicate direction of expression) | Data normalization | Reference |
|---|---|---|---|---|---|
| Pertussis (human) | RT-qPCR TaqMan Array Human miRNA panel (Applied Biosystems) | Serum | miR-202↑, miR-342-5p↑ miR-206↑, miR-487b↑, miR-576-5p↑ | cel-miR-238 | Ge et al. (208) |
| Varicella (human) | RT-qPCR TaqMan Array Human miRNA panel (Applied Biosystems) | Serum | miR-197↑, miR-629↑, miR-363↑, miR-132↑, miR-122↑ | cel-miR-238 | Qi et al. (217) |
| Influenza H1N1 (human) | miRCURY LNA microRNA Arrays (Exiqon) | Whole blood | miR-1260↑, miR-335↑*, miR-664↑, miR-26a↓, miR-576-3p↑, miR-628-3p↓ | Normalized to endogenous controls and the spike-in control | Tambyah et al. (218) |
| RT-qPCR TaqMan | 18S rRNA | ||||
| Influenza A/H1N1 virus (human) | RT-qPCR TaqMan Array Human miRNA panel (Applied Biosystems) | Serum | miR-150↑ | U6 snRNA | Moran et al. (219) |
| Avian Influenza A H7N9 (human) | RT-qPCR TaqMan Array Human miRNA panel (Applied Biosystems) | Serum | miR-17↑, miR-20a↑, miR-106a↑, miR-376c↑ | cel-miR-238 | Zhu et al. (220) |
| Hand, foot and mouth disease (human) | RT-qPCR TaqMan Array Human miRNA panel (Applied Biosystems) | Serum | miR-148a↑, miR-143↑, miR-324-3p↑, miR-628-3p↑, miR-140-5p↑, miR-362-3p↑ | cel-miR-238 | Cui et al. (215) |
| Hand, foot and mouth disease (human) | miRNA microarrays (Agilent Technologies) | Serum exosomes | miR-671-5p↓, miR-16-5p↑, miR-150-3p↓ | Standard Agilent normalization | Jia et al. (216) |
| RT-qPCR | miR-642a-3p | ||||
| Hand, foot and mouth disease (human) | nCounter® miRNA Expression assays (NanoString) | Serum | miR-494↑, miR-29b-3p↑, miR-551a↓, miR-606↓, miR-876-5p↑, miR-30c-5p↑, miR-221-3p↓, miR-150-5p↓ | Geometric mean of top 100 miRNAs | Wang et al. (119) |
| RT-qPCR TaqMan assays (Applied Biosystems) | U6 snRNA | ||||
| Human immunodeficiency virus (HIV)-associated neurological disorders (human) | RT-qPCR microRNA panels (Exiqon) | Plasma | miR-151a-5p↑, miR-194-5p↑, miR-19b-1-5p↑ | miR-23a-3p and miR-23b-3p | Kadri et al. (211) |
| HIV-encephalitis (human) | RT-qPCR microRNA panels (Exiqon) | Cerebrospinal fluid | miR-19b-2*↑, miR-937↑, miR-362-5p↑ | miR-622 and miR-1266 | Pacifici et al. (213) |
| Staphylococcus aureus-induced mastitis (bovine) | TruSeq small RNA sequencing (Illumina) | Bovine milk exosomes | miR-142-5p↑, miR-223↑ | Upper quantile normalization | Sun et al. (222) |