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. Author manuscript; available in PMC: 2017 Feb 24.
Published in final edited form as: Oncogene. 2016 Aug 15;36(8):1069–1079. doi: 10.1038/onc.2016.271

Figure 5. Inhibition of Stat3 reduces the growth of human NPC tumor xenografts in athymic nude mice.

Figure 5

(A–C) Representative photographs of harvested tumors (top) and the corresponding tumor growth curves (bottom) are shown. Tumor weights measured at the indicated times are shown at right. Female nude mice bearing xenograft tumors derived from CNE2 cells (A), HONE1 cells (B), or C666.1 cells (C) with stable Stat3 knockdown were intraperitoneally injected with phosphate-buffered saline or cisplatin (CP) at 5 mg/kg of body weight once every 2 days. (D) At the end of the experiments, the mice were humanely killed, and the tumors were excised and weighed. The data are means with standard errors. (E) Representative T-Stat3, and Jab1 expression in tissues from the same mice. Correlations of Stat3 and Jab1 staining scores are shown at right. IHC, immunohistochemistry. *P < 0.05, **P < 0.01.