Table 4.

Clinical course of patients with metachronous head and neck squamous cell carcinoma n (%)

	Group A, patients (n = 10)	Group B, patients (n = 30)	P value
Metachronous HNSCC	11 lesions	53 lesions	< 0.001
I/II	4 (36)	53 (100)
III/IV	7 (64)	0 (0)
Treatment
Local resection	2 (18)	49 (92)	< 0.001
Endoscopic resection	0	44
Surgical local resection	2	5
TPLE	3 (27)	0 (0)	0.001
Radiotherapy alone and/or chemotherapy	4 (36)	2 (4)	0.006
No treatment	2 (18)	2 (4)	0.133
Laryngeal function			< 0.001
Maintained	4 (40)	30 (100)
Lost	6 (60)	0
Outcome			0.001
Alive	3 (30)	26 (87)
Death	7 (70)	4 (13)
Death with metachronous HNSCC	6 (60)	0 (0)	< 0.001

HNSCC: Head and neck squamous cell carcinoma; TPLE: Total pharyngo-laryngo-esophagectomy.