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mTORC1/2 but not mTORC1 inhibition disrupts DDR pathways and induces replicative cell stress. (A) Immunoblot evidence for sustained DDR signaling with mTORC1/2 inhibition following genotoxic stress. SUM149 cells were treated with 2.5 μM PP242, 20 nM RAD001, or DMSO for 2 h prior to 8 Gy of IR and harvested, and equal protein amounts were used for immunoblot analysis. (B) SUM149 cells were treated with drugs as described above for 9 h prior to 8 Gy of IR and analyzed by immunoblotting.
