FIG 6.

A hypothetical model for the decrease in life span in CLas-infected psyllids as a result of accumulation of ATP. Infection with CLas enhances ATP accumulation and consequently increases adenylated energy charge (AEC) and decreases AMP/ATP and ADP/ATP ratios. As a result of the increase in AEC and the decrease in AMP/ATP and ADP/ATP ratios, the activity of AMPK will decrease and the activity of NDPK will increase in order to maintain energy homeostasis. Failure to maintain cellular homeostasis and the decrease in AMPK activity will disrupt many aspects of cellular functions and result in cell death and shorter life span in D. citri.