Figure 6.
Decreased CXCL12 and elevated CXCR7 are correlated with poor prognosis in clinical breast cancer. (a) The mRNA levels of CXCL12 and TGFβ in tumour samples were analysed in 33 breast cancer patients. N, normal tissue; T, tumour tissue. (b) The mRNA expression levels of TGFβ and CXCR7 were compared between CXCL12 low (L, n=17) and CXCL12 high (H, n=16) groups, which were divided according to the median of CXCL12 in the patients. (c, d) Relapse free survival (c) and distant metastasis free survival (d) of breast cancer patients with high- or low-CXCL12 (Affymetrix ID: 209687_at) expression. Hazard ratios (HR) and P-values (log rank P) are depicted for each survival analysis. Kaplan–Meier survival data were generated using the publicly online tool KM-plotter. (e, f) Relapse free survival (e) and distant metastasis-free survival (f) of breast cancer patients with high- or low-CXCR7 (Affymetrix ID: 212977_at) expression. Hazard ratios (HR) and P-values (log rank P) are depicted for each survival analysis. Kaplan–Meier survival data were generated using the publicly online tool KM-plotter.