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. 2017 Jan 12;8(2):318–333. doi: 10.1016/j.stemcr.2016.12.010

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

In Vivo Comparison of Developmental Potential

GFP⁺ ESCs were FACS sorted for PECAM and/or PDGFRα and injected into recipients blastocysts. Scale bar, 100 μm.

(A) E6.5 chimeric embryo generated from epiblast-primed cells showing the contribution to the embryo proper.

(B) E6.5 chimeric embryo generated from double-positive cells showing the contribution to the embryo proper.

(C) E6.5 chimeric embryo generated from double-positive cells showing the contribution to the VE (arrowhead).

(D) E6.5 chimeric embryo generated from double-positive cells showing the contribution to the PE (arrow).

(E) E6.5 chimeric embryo generated from PrE-primed cells showing the contribution to the VE (arrowhead).

(F) E6.5 chimeric embryo generated from PrE-primed cells showing the contribution to the PE (arrow).

See also Table S1.