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. 2017 Feb 16;7:42678. doi: 10.1038/srep42678

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Copyright © 2017, The Author(s)

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Mice were treated with HC-067047 at 1 h after reperfusion. Inhibitors of RISK pathway, LY294002 (LY) wortmannin (Wor), U0126 were administrated 60 min before ischemia. (A) Quantification of infarct size of myocardium at 4 h after I/R. (B) Serum concentration of TnT at 4 h after reperfusion. (C) Percentages of TUNEL-positive nuclei over total number of nuclei. (D) Cleaved caspase-3 to caspase-3 ratio. (E) Bax to Bcl-2 ratio at 4 h after I/R. n = 6–8/group, **P < 0.01, ***P < 0.001 vs vehicle, ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs HC-067047.