Table 3. Main Results of Pooled ORs and Analysis of C4,C4A and C4B CNV with Autoimmune Diseases in this Meta-Analysis.
<4 VS ≥ 4 C4 | <2 VS ≥ 2 C4A | <2 VS ≥ 2 C4B | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Classification | N(Case/Control) | OR | 95%CI | PH | OR | 95%CI | PH | OR | 95%CI | PH |
All disease | 1.46 | (1.19, 1.78) | <0.001 | 1.46 | (1.10, 1.94) | <0.001 | 1.07 | (0.93, 1.24) | <0.001 | |
SLE | 8(3672/4746) | 1.80 | (1.51, 2.13) | 0.016 | 2.13 | (1.71, 2.64) | 0.003 | 1.18 | (0.94, 1.47) | <0.001 |
Other | 8(4991/6353) | 1.05 | (0.80, 1.38) | <0.001 | 0.94 | (0.64, 1.38) | <0.001 | 0.96 | (0.80, 1.16) | 0.013 |
Ethnicity | ||||||||||
Asian | 7(4992/7380) | 1.13 | (0.88, 1.45) | <0.001 | 0.98 | (0.65, 1.49) | <0.001 | 0.96 | (0.82, 1.12) | 0.021 |
Caucasian | 9(3671/3719) | 1.91 | (1.42, 2.56) | <0.001 | 2.05 | (1.49, 2.83) | <0.001 | 1.25 | (0.96, 1.63) | <0.001 |
PH: P value for heterogeneity.