Table 4. Clinical characteristics in BM patients and genotypes and allele frequencies of TLR9 rs352139※.
| Characteristics | Patients with symptoms or parameters defined (%)& | OR (95%CI) | P value# | |
|---|---|---|---|---|
| Seizures | Yes (n = 95) | No (n = 122) | ||
| GG | 22 (23.2) | 13 (10.7) | 1 | Ref. |
| GA | 49 (51.6) | 60 (49.2) | 2.072 (0.947–4.532) | 0.065 |
| AA | 24 (25.3) | 49 (40.2) | 0.289 (0.125–0.672) | 0.003 |
| G | 93 (48.9) | 86 (35.2) | 1 | Ref. |
| A | 97 (51.1) | 158 (64.8) | 0.568 (0.386–0.836) | 0.004 |
| Bacteremia | Yes (n = 65) | No (n = 152) | ||
| GG | 5 (7.7) | 30 (19.7) | 1 | Ref. |
| GA | 33 (50.8) | 76 (50.0) | 2.604 (0.929–7.299) | 0.062 |
| AA | 27 (41.5) | 46 (30.3) | 3.522 (1.221–10.158) | 0.016 |
| G | 43 (33.1) | 136 (44.7) | 1 | Ref. |
| A | 87 (66.9) | 168 (55.3) | 1.637 (1.066–2.519) | 0.024 |
| Glucose in CSF (mmol/L)* | ≤ 1.5 (n = 61) | >1.5 (n = 151) | ||
| GG | 8 (13.1) | 26 (17.2) | 1 | Ref. |
| GA | 32 (52.5) | 75 (49.7) | 1.387 (0.567–3.390) | 0.472 |
| AA | 21 (34.4) | 50 (33.1) | 1.365 (0.532–3.502) | 0.517 |
| G | 48 (39.3) | 127 (42.1) | 1 | Ref. |
| A | 74 (60.7) | 175 (57.9) | 0.894 (0.582–1.373) | 0.608 |
※There were no statistically significant differences between SNPs of TLR9 rs352139 in other clinical characteristics including consciousness, subdural effusion, hearing loss, CSF white cell numbers, CSF proteins and long-term prognosis (all p > 0.05).
*Information was only available in 212 subjects.
Abbreviations: CSF, cerebrospinal fluid; OR, odds ratio; CI, confidence interval.