Figure 6. BAR502 activates FXR and reduces the synthesis of primary bile acids.

Bile acid pool was assayed by measuring fecal levels of (A) unconjugated (CA, HCA, CDCA, UDCA, CDCA, DCA, LCA) and (B) conjugated (TβMCA, TCA, THCA, TCDCA, TDCA) bile acids. Results are the mean ± SE of 5 mice per group. *p < 0.05 versus naive mice, #p < 0.05 versus HFD mice.