Table 1. Single nucleotide polymorphisms that are associated with penicillin resistance.

BP Position	RF importance	RF p-value	CMH p-value	Annotation	Gene
1613086	20.62957785	0	3.308E-99	penicillin-binding protein 2b	penA
1612897	19.83961807	0	6.649E-85	penicillin-binding protein 2b	penA
333792	11.86365577	8.69E-98	1.234E-99	Holliday junction-specific endonuclease	recU
333282	11.70867819	1.55E-18	5.304E-55	penicillin-binding protein 1 A	pbp1A
334107	11.29654702	7.83E-162	9.151E-72	Holliday junction-specific endonuclease	recU
334639	10.42365322	0	1.203E-68	hypothetical protein	—
294991	10.24670847	0	5.276E-60	phospho-N-acetylmuramoyl-pentapeptide-transferase	mraY
335104	8.53526957	3.3E-17	2.659E-68	DivIVA protein	—
333345	7.379638353	6.46E-16	8.607E-24	penicillin-binding protein 1 A	pbp1A
1613422	7.320298527	9.51E-56	4.344E-55	penicillin-binding protein 2b	penA
292563	7.167180495	8.14E-08	1.294E-55	penicillin binding protein 2x	pbpX
332247	6.771832321	4.27E-26	3.671E-55	penicillin-binding protein 1 A	pbp1A
335955	6.631966798	8.25E-35	9.742E-45	RNA methylase family protein	—
1613770	6.108715366	7.27E-87	2.023E-78	penicillin-binding protein 2b	penA
333386	5.891738108	4.68E-13	8.607E-24	penicillin-binding protein 1 A	pbp1A
1532326	5.159428663	2.95E-11	4.143E-72	dihydrofolate reductase	dyr
1531915	5.154251817	1.21E-11	1.717E-20	ATP-dependent protease ATP-binding subunit ClpX	clpX
295737	4.619274035	1.67E-75	7.271E-49	ATP-dependent protease ATP-binding subunit ClpL	clpL
296748	4.473732826	4.15E-08	2.701E-36	ATP-dependent protease ATP-binding subunit ClpL	clpL
2193975	4.432372852	3.41E-61	8.905E-27	elongation factor Ts	tsf