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. 2017 Feb 10;6(2):e127. doi: 10.1038/cti.2017.1

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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EBV infection alters critical markers involved in antigen presentation and co-stimulation of the B cell. RNA sequencing was performed on spleen-derived CD3⁻CD20⁺ B cells from immunologically healthy marmosets (n=2) and marmoset B-LCLs (n=2), with 10 million high-quality uniquely mapped reads were obtained per sample, to determine the effect of EBV infection on gene expression involved in antigen presentation and co-stimulation pathways. EBV infection resulted in differential expression (FDR<0.05, logFC=±1) in pathways associated with cell growth/survival functions, metabolic processes and antigen presentation/co-stimulation. (a) Shown is a heatmap depicting genes associated with the selected categories antigen presentation, lysosome and proteasome (processing) function chosen from the list of differentially expressed genes. Tabular data for these genes are in Supplementary Table 1. The scaled expression value (Z score) is displayed in red-green color scheme with red indicating lower expression and higher expression in green. (b) Depicted are the top five up- and downregulated pathways.