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. 2017 Feb 10;6(2):e127. doi: 10.1038/cti.2017.1

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Copyright © 2017 The Author(s)

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B-LCL rapidly alters CD279 (PD-1) expression in T-cell subsets. Expression of CD279 (PD-1) on MNC-derived T cells (n=14) was analyzed by flow cytometry following co-culture with B-LCLs. The figure depicts percentages of CD3⁺CD4⁺CD45RA^+/− (top panel)- and CD3⁺CD8⁺CD45RA^+/− (bottom panel)-expressing CD279. In all T-cell subsets examined following 48 h of co-culture, profound increases in the percentage of CD279⁺ cells were observed. In earliest time points measured (0 h) taken for calibration purposes, whereby cells were co-cultured and immediately centrifuged and stained for FACS, expression of CD279 was also increased in either CD4 or CD8 T-cell subsets expressing CD45RA. Statistical significance of P<0.05 is indicated by *, significance of P<0.01 is indicated by ** and P<0.001 is indicated by ***.