Table 4. Amplitudes and Implicit Times in Full-Field and Focal Macular Electroretinography.
| Least squares mean (95% Confidence Interval) |
Difference of least squares mean (95% Confidence Interval), P value |
|||
|---|---|---|---|---|
| ONH | Controls | ONH–Controls | P value | |
| Full-field ERG Amplitude (μV) | ||||
| Rod b-wave | 211.4 (185.1 to 237.8) | 201.5 (178.8 to 224.3) | 9.9 (−25.4 to 45.2) | 0.5727 |
| Combined rod-cone a-wave | 385.8 (361.7 to 409.9) | 373.1 (352.3 to 393.9) | 12.7 (−20.2 to 45.6) | 0.4396 |
| Combined rod-cone b-wave | 491.2 (451.2 to 531.2) | 519.4 (473.1 to 565.6) | −28.2 (−89.8 to 33.5) | 0.3604 |
| Cone a-wave | 72.9 (53.9 to 91.8) | 73.8 (66.9 to 80.7) | −0.9 (−21.2 to 19.3) | 0.9266 |
| Cone b-wave | 139.9 (120.7 to 159.0) | 146 (133.4 to 158.7) | −6.2 (−29.1 to 16.8) | 0.5906 |
| i-wave | 12.6 (7.8 to 17.5) | 11.0 (6.8 to 15.2) | 1.6 (−5.0 to 8.2) | 0.6210 |
| Photopic negative response | 28.9 (17.9 to 39.8) | 51.7 (44.9 to 58.5) | −22.9 (−36.0 to −9.7) | 0.0011* |
| 30-Hz flicker | 166.9 (153.1 to 180.8) | 172.2 (159 to 185.4) | −5.2 (−24.3 to 13.8) | 0.5806 |
| Full-field ERG Implicit Time (ms) | ||||
| Rod b-wave | 107.8 (105.1 to 110.6) | 113.6 (108.1 to 119.2) | −5.8 (−12.0 to 0.4) | 0.0648 |
| Combined rod-cone a-wave | 10.6 (10.1 to 11.0) | 10.6 (10.2 to 11.0) | 0.0 (−0.6 to 0.6) | 0.9310 |
| Combined rod-cone b-wave | 52.6 (50.8 to 54.5) | 50.8 (47.9 to 53.7) | 1.8 (−1.6 to 5.3) | 0.2866 |
| Cone a-wave | 15.8 (15.3 to 16.3) | 16.0 (15.7 to 16.3) | −0.2 (−0.8 to 0.4) | 0.4460 |
| Cone b-wave | 36.9 (35.8 to 38.1) | 38.3 (36.2 to 40.5) | −1.4 (−3.8 to 0.9) | 0.2319 |
| i-wave | 56.5 (54.4 to 58.5) | 56.1 (53.9 to 58.2) | 0.4 (−2.6 to 3.4) | 0.7866 |
| Photopic negative response | 66.8 (65.2 to 68.3) | 65.7 (64.0 to 67.4) | 1.0 (−1.2 to 3.3) | 0.3626 |
| 30-Hz flicker | 30.0 (29.0 to 30.9) | 29.6 (28.8 to 30.3) | 0.4 (−0.8 to 1.6) | 0.5081 |
| Focal mauclar ERG Amplitude (μV) | ||||
| a-wave | 0.58 (0.48 to 0.68) | 0.99 (0.87 to 1.11) | −0.41 (−0.56 to −0.26) | <0.0001* |
| b-wave | 1.85 (1.56 to 2.13) | 2.51 (2.19 to 2.84) | −0.67 (−1.08 to −0.25) | 0.0026* |
| Photopic negative response | 0.54 (0.43 to 0.65) | 1.32 (1.08 to 1.55) | −0.78 (−1.03 to −0.52) | <0.0001* |
| Focal macular ERG Implicit Time (ms) | ||||
| a-wave | 22.4 (21.9 to 22.9) | 23.1 (22.6 to 23.5) | −0.6 (−1.3 to 0.1) | 0.0701 |
| b-wave | 37.8 (37.1 to 38.4) | 38.5 (37.5 to 39.4) | −0.7 (−1.8 to 0.4) | 0.2009 |
| Photopic negative response | 64.4 (62.3 to 66.5) | 64.9 (62.8 to 66.9) | −0.4 (−3.4 to 2.6) | 0.7668 |
ERG = electroretinography; ONH = optic nerve hypoplasia; ms = millisecond; *P < 0.05.