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. 2017 Feb 16;7:42396. doi: 10.1038/srep42396

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(a) Ang II generation by ACE-dependent or independent pathways in a variety of human organs in physiologic and pathophysiologic conditions. (b) Gene array analysis revealed that CMA1 expression was significantly upregulated in all hypoxic CNE2 cells; N1, N2 and N3 referred to triplicates in normoxic condition; H1, H2 and H3 referred to triplicates in hypoxic condition. (c) CMA1 expression in CNE2 cells was confirmed by protein analysis; hypoxia-1, 5% O2 condition; hypoxia-2, 1% O2 condition. (d) ELISA analysis showed an obvious decrease of Ang II levels in hypoxic cells when the expression of chymase was suppressed by shRNA. *P < 0.05; **P < 0.01; ns, no significance. ACE, angiotensin-converting enzyme; Ang I, angiotensin I; Ang II, angiotensin II. CMA, chymase; ELISA, enzyme linked immunosorbent assay.