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. 2017 Feb 16;7:42396. doi: 10.1038/srep42396

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(a) Exogenous lactate increased the expression of chymase and rennin in CNE2 cells, whereas the pretreatment with oxamic acid (OA) suppressed the expression of chymase and renin under normoxic as well as hypoxic conditions. (b) The impact of the acidification with HCl or alkalinization with NaHCO₃ on the expression of chymase and rennin in CNE2 cells.