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. 2017 Feb 16;7:42701. doi: 10.1038/srep42701

Figure 2. Expression of pro-inflammatory mediators in the kidney after HIR.

Figure 2

(a,b) qRT-PCR analysis of TNFα, IL-6, MCP-1, and MIP-2 mRNA in kidney tissue from rats in the CTR group, HIR, Oct. + HIR, and Oct. + HIR+3MA after 60 minutes of liver ischemia and 24 hours of reperfusion. (c) Immunohistochemistry staining results of TNFα, IL-6, MCP-1, and MIP-2 in kidney tissue from rats in the CTR group, HIR, Oct. + HIR, and Oct. + HIR+3MA after 60 min. of liver ischemia and 24 hrs of reperfusion. (200× magnification, Bar = 200 μm). Ten rats were included in each study group. The results are presented as mean ± S.D. *P < 0.05 HIR vs. CTR group, #P < 0.05 Oct. + HIR νs. HIR group, and $P < 0.05 Oct. + HIR+3MA νs. Oct. + HIR group. AKI, acute kidney injury; CTR, control; HIR, hepatic ischemia-reperfusion; Oct. + HIR, octreotide pretreatment and hepatic ischemia-reperfusion and Oct. + HIR+3MA, octreotide and 3-methyladenine pretreatment and hepatic ischemia-reperfusion.