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. 2017 Feb 16;7:42604. doi: 10.1038/srep42604

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Schematic diagram describing the components and metrics from Seahorse assays used in the PCA; Bioenergetic Health Index (BHI) calculation is described in methods. (B) Metabolic parameters individually tested for correlation (Pearson) to PLX4720 IC50 of the cells. (C) The first principle component of a linear combination of glycolysis and glycolytic reserve correlates with IC50.