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. 2017 Feb 1;10(2):119–126. doi: 10.1242/dmm.027482

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Atrx-cHet mice perform poorly in the Morris water-maze paradigm. (A) Atrx-cHet mice (n=13) spent more time finding the platform compared with control mice (n=11) over the four consecutive days of training (*P<0.05). They swam longer distances but at a lower speed compared with control mice (*P<0.05). (B) Control mice spent more time swimming in the target quadrant (T) compared with the left (L) and opposite (O) quadrants (*P<0.05) on the day 5 probe test, whereas Atrx-cHet mice spent ∼25% of their time in each of the quadrants. (C) In the cued version of the Morris water maze, Atrx-cHet mice (n=11) were unable to learn the location of the visible platform, whereas the control mice could effectively learn this task (n=11). Data are represented as means±s.e.m. and a two-way ANOVA test was done. *P<0.05.