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. 2017 Feb 1;10(2):89–104. doi: 10.1242/dmm.027649

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — The anatomy of the human and mouse stomach. A schematic of the anatomy of the human and mouse stomach and the structure of gastric glands. Two types of columnar mucosa line the human stomach: the antrum is lined with antral glands, whilst the corpus and fundus are lined with deeper oxyntic, or corpus glands (see Glossary, Box 1). The murine stomach has areas that are analogous to the human stomach, including antral and corpus glands, and it also has a forestomach lined with squamous epithelium. Stem cells that reside at the base of the gland generate the antral gland. Following asymmetric cell division in the stem cell zone, daughter cells migrate upwards towards the gastric lumen and differentiate into mucous neck, surface mucous and endocrine cells. In corpus glands, the stem cell niche is located at the isthmus of the gland. Cells migrate upwards from the stem cell zone and differentiate into surface mucous cells. Other cells migrate down the gland and differentiate into acid-secreting parietal cells, endocrine cells, or zymogen-secreting (see Glossary, Box 1) chief cells.