Transduction cascade of vertebrate photoreceptor. Steps contributing to rate of activation are indicated by green arrows; steps contributing to rate of inactivation by red arrows. Arr, arrestin; cGMP, 3′, 5′-cyclic guanosine monophosphate; GAP, GTPase-activating protein; GDP, guanosine diphosphate; GCAP, guanylyl cyclase-activating proteins; GMP, guanosine monophosphate; GRK, G-protein receptor kinase (rhodopsin kinase); GTP, guanosine triphosphate; hν, light; PDE, phosphodiesterase 6; Pi, inorganic phosphate; Rh, rhodopsin; Rh*, light-activated rhodopsin.