Fig. 6.

Assembly of enhancer-protein complexes is destabilised in the absence of Jmjd2c in ESC-derived EpiSCs. (A) Mapping of poised (PE) and epiblast-specific enhancer sites (E1-E4) at Fgf5 locus (Buecker et al., 2014). (B) Enrichment levels for Jmjd2c, p300, Oct4, G9a, Med1 and Smc1a at indicated sites as assessed by ChIP-qPCR in wild-type and Jmjd2c-KO cEpiSCs. Fold enrichment is relative to an intergenic region (dotted line) and represents mean±s.e.m. of three experiments. *P<0.05; Mann–Whitney U-test.