Fig. 8.

Loss of αvβ6 integrin in aged Mdr2^−/−;Itgb6^−/− mice confers protection from cirrhosis-associated primary liver cancer. (A) Representative macroscopic findings in livers of aged Mdr2^−/− and Mdr2^−/−;Itgb6^−/− mice. Arrowheads indicate visible tumors >1 mm in size. (B) Tumor incidence (left panel), tumor muliplicity (middle panel), and overall tumor burden (right panel) analyzed in a total of 12 mice of each genotype at age 12 months. Data are expressed as means ± standard error of the mean. *P < 0.05 compared to Mdr2^−/− mice (two-way analysis of variance followed by Bonferroni’s posttest). Abbreviation: n.d., not detected.