Table 3. Results from Mixed Effects Model of Subjects Intensity of Depression Symptoms and Tissue Type Interaction (W/G Interaction), and Total Tissue Metabolite Concentrations.
| Effect type | Beta | SE | t | Degrees of freedom | p-value | |
|---|---|---|---|---|---|---|
| PCr | ||||||
| HAM-D-17 | W/G interaction | 0.01006 | 0.0071 | 1.42 | 3730 | 1.0 |
| Main effect | 0.37117 | 1.7618 | −0.21 | 97 | 1.0 | |
| SQ depression | W/G interaction | −0.00231 | 0.0048 | −0.46 | 3445 | 1.0 |
| Main effect | 2.20281 | 1.2381 | 1.78 | 50 | 0.813 | |
| SQ anxiety | W/G interaction | 0.00565 | 0.0044 | 1.28 | 3456 | 1.0 |
| Main effect | 2.96243 | 1.1327 | 2.62 | 50 | 0.117 | |
| SQ somatic | W/G interaction | 0.02087 | 0.0054 | 3.86 | 3446 | 0.001 |
| Main effect | ||||||
| SQ hostility | W/G interaction | 0.01020 | 0.0055 | −1.84 | 3447 | 0.656 |
| Main effect | 2.81031 | 1.3134 | 2.14 | 52 | 0.371 | |
| Pi | ||||||
| HAM-D-17 | W/G interaction | 0.01563 | 0.0045 | 3.45 | 3714 | 0.006 |
| Main effect | ||||||
| SQ depression | W/G interaction | 0.01242 | 0.0031 | 4.05 | 3436 | <0.001 |
| Main effect | ||||||
| SQ anxiety | W/G interaction | 0.00587 | 0.0028 | 2.10 | 3439 | 0.360 |
| Main effect | −0.12581 | 0.5864 | −0.21 | 55 | 1.0 | |
| SQ somatic | W/G interaction | 0.00125 | 0.0035 | 0.36 | 3435 | 1.0 |
| Main effect | −0.48258 | 0.6865 | −0.70 | 57 | 1.0 | |
| SQ hostility | W/G interaction | 0.00163 | 0.0036 | 0.46 | 3434 | 1.0 |
| Main effect | −0.00023 | 0.6991 | −0.003 | 56 | 1.0 |
A significant effect in the higher order interaction precluded further testing. Individual effects in each tissue type for significant models are described in the text.