Table 2. Transdiagnostic Differences in Intranetwork Connectivity in the FEP, MDD, and PTSD Groups Relative to the HC Groupa.
| Region | x, y, z |
Degree centrality (±SEM) |
FEP+PTSD+MDD<HC |
|||||
|---|---|---|---|---|---|---|---|---|
| FEP | PTSD | MDD | HC | KC | z-score | p-value | ||
| Ventral medial prefrontal cortex | 3, 23, 16 | 0.13 (0.02) | 0.17 (0.02) | 0.14 (0.01) | 0.22 (0.01) | 10 | 4.21 | 0.015 |
| Left posterior inferior parietal cortex | −45, −82, 25 | 0.20 (0.02) | 0.20 (0.02) | 0.20 (0.02) | 0.22 (0.01) | 1 | 4.16 | 0.018 |
Abbreviations: FEP, first-episode psychosis; FWE, family-wise error; PTSD, post-traumatic stress disorder; MDD, major depressive disorder; HC, healthy controls; x y z, Montreal Neurological Institute coordinates; KC, cluster size.
All p-values are reported after FWE correction for multiple comparisons.
a
In contrast, there were no disease-specific differences in intranetwork connectivity in the FEP group relative to MDD, PTSD and HC groups.