FIG 2 .
Dose response of DG70 against M. tuberculosis mc26206 in J774A.1 murine macrophages. J774A.1 macrophages were infected with 104 CFU/ml of M. tuberculosis (T0, red bar) and treated with DG70 at final concentrations of 0.5, 1, 2.5, 5, and 10× its MIC. Macrophages treated with either bedaquiline (BDQ) or isoniazid (INH) at 10× MIC were used as positive controls. CFU were determined after 3 days of treatment and were back calculated to CFU per milliliter. T0 shows the initial CFU used for infecting macrophages. Means and standard deviations from three independent experiments are shown. The Student t test was used to determine statistical significance between DMSO and different treatments. **, P ≤ 0.01.