FIG 6 .

DG70 inhibits oxygen consumption and ATP synthesis in mycobacteria. (A) Effect of DG70 on oxygen consumption. Mycobacterial cells containing 0.01% methylene blue were treated with thioridazine (THZ), isoniazid (INH), or DG70 at the indicated concentrations (×MIC). Cultures were supplemented with MK4 (400 µM) where indicated. Decolorization of methylene blue, as an indicator of oxygen consumption, was monitored at 665 nm. (B) The ATP levels of 1 ml of cellular lysate of BCG (OD₅₉₅ = 0.4) after 3 days of treatment with the indicated compounds are shown. MK4 (400 µM) was added as a supplement as indicated.