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. 2017 Feb 14;8(1):e02022-16. doi: 10.1128/mBio.02022-16

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Copyright © 2017 Sukheja et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

PMC Copyright notice

FIG 7 — Activity of DG70 against nonreplicating M. tuberculosis. M. tuberculosis starved for 6 weeks in PBS (nutritionally deprived persistence model) was exposed to various concentration of DG70 and 10× MIC of isoniazid (INH), bedaquiline (BDQ), PA824, thioridazine (THZ), and rifampin (RIF) for 7 days and then plated to determine viability. Menaquinone (MK4) at a 400 µM concentration was used to test for reversal of the killing mediated by DG70 in the nutrient-deprived M. tuberculosis. Experiments were carried out in duplicate, and each dilution was plated in triplicate. CFU counts were back calculated to CFU per milliliter. Results are shown as means and standard deviations.