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Single nucleotide polymorphisms detected in M. tuberculosis and M. bovis BCG spontaneous mutants resistant to DG70
| Strain | DG70 MIC90 (µg/ml) | Gene(s) mutated | Amino acid change |
|---|---|---|---|
| H37Rv | |||
| 70P3a | >80 | menG, sigL | V20A |
| 70P7a | 40 | menG, ponA1 | F118L |
| DRM1 | >80 | menG | W75A |
| DRM7 | >80 | menG | S188A |
| BCG | |||
| 70B1 | 19.2 | menG | A60V |
| 70B2 | 19.2 | menG | A60V |
| 70B4 | 19.2 | menG | D7H |
| 70R1 | 9.6 | menG | G99V |
| 70R2 | 9.6 | menG | G99V |
| 70R5 | 19.2 | menG | D7H |
| 70S1 | >40 | menG | R43W |
| 70S3 | 9.6 | menG | V136F |
| 70S4 | 9.6 | menG | R190M |
Whole-genome-sequenced strains.
