TABLE 3 .
Synergy between DG70 and antitubercular drugs
| Drug combination | MIC (µM) |
FIC | FIC index, categorya | |
|---|---|---|---|---|
| Alone | In combination | |||
| BDQ | 0.39 | 0.16 | 0.4 | 0.5, synergistic |
| DG70 | 12.5 | 1.5 | 0.1 | |
| PA824 | 0.1 | 0.1 | 1.0 | 1.0, additive |
| DG70 | 12.5 | 0.35 | 0.03 | |
| THZ | 6.25 | 3.12 | 0.5 | 0.7, additive |
| DG70 | 12.5 | 3.12 | 0.2 | |
| INH | 0.39 | 0.09 | 0.2 | 0.4, synergistic |
| DG70 | 12.5 | 3.12 | 0.2 | |
| RIF | 0.02 | 0.005 | 0.25 | 0.5, synergistic |
| DG70 | 12.5 | 3.1 | 0.25 | |
| EMB | 6.25 | 3.12 | 0.5 | 0.6, additive |
| DG70 | 12.5 | 1.5 | 0.12 | |
a
FIC categories: ≤0.5, synergistic; >0.5 to ≤1, additive; >1 to <4, no interaction; ≥4, antagonism.