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Model showing the different populations of FANCD2/γH2AX/HPV DNA and p-SMC1/ γH2AX/HPV DNA foci found in HPV-positive cells upon differentiation. p-SMC1 and FANCD2 are rarely found together in the same nuclei. The cells with p-SMC1/γH2AX bound to HPV genomes likely represent the amplifying population, while those with FANCD2/γH2AX are not amplifying.
