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Colorectal Cancer Is a Heterocellular System. Healthy colon and colorectal cancer (CRC) immunohistochemistry sections (from the Protein Atlas, www.proteinatlas.org) [83] illustrate the explicit heterocellularity of intestinal tissue. Both healthy and CRC tissue contain epithelial cells (EpCAM+), myeloid macrophages (CD11b+), T helper lymphocytes (CD4+), T cytotoxic lymphocytes (CD8+), B lymphocytes (CD19+), and mesenchymal fibroblasts (αSMA+).
