Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Protoporphyrin-dependent pathway to protoheme IX synthesis. An overview of the three-step reaction and intermediates from coproporphyrinogen to protoheme, along with the enzymes responsible for the reaction, is shown. Coproporphyrinogen III is oxidatively decarboxylated at two propionate groups to yield protoporphyrinogen IX. This intermediate is oxidized to protoporphyrin, which is converted into heme upon iron insertion.
