TABLE 2.
Taxonomic distribution of enzymes specific for the siroheme-, coproporphyrin-, and protoporphyrin-dependent heme synthesis pathways
| Major taxon analyzed | No. of organisms capable of heme biosynthesis | No. of UroD+ genomes per taxon that utilize: |
No. of UroD+ genomes per taxon that utilize: |
|||||
|---|---|---|---|---|---|---|---|---|
| ChdC | AhbD | CgdH | CgdC | HemYa | PgdH2 | PgdH1 | ||
| Total | 645/651 | 153 | 61 | 390 | 387 | 231 | 326 | 99 |
| Actinobacteria | 81 | 83 | 16 | 2 | 79 | 1 | ||
| Firmicutes | 38 | 37 | 12 | 39 | ||||
| Chloroflexi (green nonsulfur bacteria) | 7 | 6 | 3 | 2 | 1 | 7 | 2 | |
| Deinococcus-Thermus | 9 | 9 | 2 | 2 | 1 | 9 | 1 | |
| Proteobacteria | ||||||||
| Alphaproteobacteria | 106 | 70 | 101 | 1 | 105 | 6 | ||
| Betaproteobacteria | 61 | 52 | 55 | 2 | 58 | 3 | ||
| Gammaproteobacteria | 163 | 2 | 3 | 136 | 144 | 11 | 70 | 82 |
| Epsilonproteobacteria | 27 | 27 | 25 | |||||
| Zetaproteobacteria | 1 | 1 | 1 | 1 | ||||
| Deltaproteobacteria | 19 | 13 | 4 | 4 | 17 | 1 | 2 | |
| Acidobacteria | 3 | 3 | 1 | 1 | 1 | 3 | ||
| Aquificae (class) | 9 | 2 | 7 | 6 | 3 | |||
| Armatimonadetes | 1 | |||||||
| Bacteroidetes-Chlorobi; Bacteroidetes | 52 | 49 | 44 | 12 | 44 | |||
| Bacteroidetes-Chlorobi; Chlorobi (green sulfur) | 9 | 9 | 9 | 1 | ||||
| Chlamydiae-Verrucomicrobia group | 10 | 2 | 7 | 6 | 10 | |||
| Cyanobacteria | 25 | 14 | 25 | 8 | 18 | |||
| Deferribacteres | 2 | 2 | 2 | |||||
| Gemmatimonadetes | 1 | 1 | 1 | 1 | ||||
| Nitrospira | 3 | 1 | 2 | 1 | 3 | |||
| Planctomycetes | 7 | 7 | 1 | 7 | ||||
| Spirochaetes | 5 | 5 | 1 | 4 | 1 | |||
| Synergistetes | 1 | |||||||
| Thermodesulfobacteria | 2 | |||||||
| Chrysiogenetes | 1 | 1 | 1 | |||||
| Caldithrix | 1 | 1 | 1 | |||||
| Thermobaculum | 1 | 1 | ||||||
a
“HemY” refers to the combined number of CgoX and PgoX enzymes.