Figure 1.

Telomeres Elongate during In Vivo Reprogramming

(A) Schematic representation of the induction of in vivo reprogramming in i4F mice.

(B and C) Left: representative immuno-FISH images showing OCT4 (green) and telomeres (red) in (B) the large intestine and (C) the pancreas of reprogrammable mice after induction of in vivo reprogramming. White dotted lines mark the reprogrammed areas. Scale bars, 25 μm. Right: quantification of telomere signal in in vivo reprogrammed cells and the corresponding non-reprogrammed control cells. Error bars denote SE. Statistical analysis by Student's t test. n, number of nuclei. Number of mice analyzed = 3.

See also Figures S1, S4, and S5.