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. 2016 Aug 17;7(37):58768–58778. doi: 10.18632/oncotarget.11356

Figure 2. Zbtb1 prevents a default myeloid differentiation of LMPP in lymphoid inducing conditions.

Figure 2

A. FACS analysis of cells obtained after co-cultured with OP9 or OP9-DL1 stromal cells in the presence of lymphoid (IL-7 and Flt3l) and absence of myeloid cytokines for 8 days to initiate lymphoid development. The numbers indicate the proportion of cells obtained within the gates. B. Representative Giemsa staining showing the morphology of cells obtained in the co-cultures represented in (A). C. FACs analysis of cells obtained after a 3-day co-culture of sorted LMPP cells. The numbers indicate the proportion of cells obtained within the gates. D. Gram plot showing the number of cells obtained during the co-cultures represented in (C). Each dot corresponds to data from a mouse. Horizontal bars represent the mean. E. Gram plot showing the number of myeloid colonies obtained after culture of sorted LMPP cells in methylcellulose in the presence of myeloid cytokines. Each dot corresponds to data from a mouse.