Figure 6. Mc suppresses PC3 tumor growth in a mouse xenograft model.
PC3 cells (5.6 × 106 per mouse) were injected into five-week-old nude mice. When solid tumors grew to about 50 mm3, the mice received intraperitoneal injections of either vehicle control or Mc (10 mg/kg) daily for 20 days. Tumor sizes and body weights were measured every two days. (A) Effect of Mc on mouse body weight. (B) Images of xenograft tumors treated with Mc and controls on day 20. (C) Effect of Mc on xenograft tumor volume. *p < 0.05. (D) Expression patterns of PCNA, TUNEL, SUMO1 and SUMO2/3 were examined by immunohistochemistry in the xenograft tumors on day 20 in each group. Original magnification, w400.