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. 2016 Jul 28;7(37):59070–59086. doi: 10.18632/oncotarget.10887

Figure 6. Clinical significance of UHRF1 expression in RCC.

Figure 6

(A) UHRF1 was highly expressed in sunitinib-treated RCC compared with that in sunitinib-naïve RCC (P = 0.0049). (B) The overall survival rate of patients with high UHRF1 expression was significantly lower than that of patients with low UHRF1 expression (P < 0.0001). (C) Multivariate Cox proportional hazards model for prediction of overall survival showed high UHRF1 expression, advanced disease stage, and age at diagnosis were significant prognostic factors (P < 0.0001, P < 0.0001, P = 0.0005, respectively). (D) High expression of UHRF1 was observed in sunitinib-treated RCC specimens.