Figure 2. Distinct overall activities in RAS-RAF-MEK-MAPK cascade and PI3K-AKT pathway in RMPA glioma subtypes.
Formalin-fixed and paraffin-embedded RMPAhigh (n = 10) and RMPAlow (n = 9) glioma samples of the CGGA mRNA-seq database were sectioned and stained for p-ERK and p-AKT. Representative staining results of p-ERK and p-AKT (at a magnification of x40), the staining results summarized as immunoreactive score (IRS), the age at diagnosis and survival of the corresponding patients are shown.