Figure 3. Distinct chromosomal alterations in RMPA^high and RMPA^low gliomas.

The SNP6.0 data from 334 gliomas in the TCGA mRNA-seq data set and the 50k HindIII SNP array data from 205 gliomas in the Rembrandt data set were analyzed using GISTIC2.0 at an amplitude threshold of ± 0.2. The arm-level chromosomal gaines or losses in the RMPA^high and RMPA^low gliomas are depicted. In the TCGA mRNA-seq dataset, ~80% of the RMPA^high gliomas showed amplification of Chr 7 accompanied with loss of chr 10, and ~50% of the RMPA^low gliomas showed co-deletion of chr 1p and chr 19q. A similar trend was observed in the Rembrandt data set.