Table 3. Immunogenicity of native HLA-B*0702 restricted peptides, number of responding mice/number of vaccinated mice, peptides in grey were withdrawn from the selection process, *MAGE-A3274 was selected for further optimization because the immune response it generated was very weak (see Figure 3).
Antigen | Peptide | Sequence | Immunogenicity |
---|---|---|---|
Her2/neu | Her2/neu760 | SPKANKEIL | 4/9 |
Her2/neu246 | GPKHSDCLA | 0/9 | |
Her2/neu1069 | APRSPLAPS | 5/7 | |
Her2/neu1151 | SPREGPLPA | 1/3 | |
MAGE-A1; MAGE-A4 | MAGE-A1267 | GPRALAETS | 0/3 |
MAGE-A2; MAGE-A6 | MAGE-A2274 | GPRALIETS | 0/3 |
MAGE-A3, MAGE-A12 | MAGE-A3274 | GPRALVETS | 2/3* |
CEA | CEA188 | SPRLQLSND | 0/3 |
HSP70 | HSP70466 | APRGVPQIEV | 3/3 |
P53 | P5363 | APRMPEAAP | 3/3 |