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. 2016 Aug 5;7(37):59417–59428. doi: 10.18632/oncotarget.11086

Table 4. Immunogenicity of optimized HLA-B*0702 restricted peptides and cross recognition of the native peptides.

Antigen Peptide Sequence Immunogenicity against optimized peptide Immunogenicity against native peptide
HER2/neu HER2/neu246A1 APKHSDCLA 8/12 5/12
MAGE-A MAGE-A274 L9 GPRALVETL 18/18 MAGE-A1267 3/8 MAGE-A2274 3/5 MAGE-A3274 4/5
CEA CEA188L9 SPRLQLSNL 6/6 6/6

HLA-B*0702 mice were vaccinated twice with the optimized peptides. Specific CTLs were detected by cytotoxicity or IFNγ ELISPOTs against target cells loaded with the optimized peptide or the native peptide, results are presented as number of responding mice/number of vaccinated mice.