Figure 5. Loss of XRCC1 sensitized A549 cells to oleandrin-induced cell death.

A. Western blot analysis of XRCC1 and Actin in A549 cells following indicated siRNA transfection. B. A549 cells were incubated with oleandrin (0.02ug/ml) for 12 hours, 24 hours after the transfection of XRCC1 siRNA. Cell death was detected with FACS analysis. C, D, E. Quantification of (B) for indicated values. All data represent mean±SEM (n=3). ***P<0.001.